Cost-Effectiveness
Welcome back to part three of our four part series on the overall state of chiropractic as we enter the calendar year of 2022. Parts one and two covered patient satisfaction and clinical outcomes in chiropractic as well as direct comparisons to the healthcare industry as a whole.
Today I will continue that trend by discussing chiropractic through the lens of cost effectiveness or value.
In the US alone, the estimated cost of musculoskeletal pain on the healthcare system (led by the spine) has topped 1 trillion dollars. Complicating things further, musculoskeletal pain is listed as the most common cause of long term pain and disability in the US as well. (162)
With costs comparable to the GDP of Mexico, it becomes important to find solutions with the highest level of cost-effectiveness. So how do we measure cost-effectiveness or value?
Value, as it relates to medical care, is calculated by dividing the clinical outcome by the cost of delivering care represented by the equation below:

Considering that evidence-based chiropractors deliver above-average clinical outcomes at low expense, consumers could expect their value to the healthcare system to be high and this expectation is supported by the research. Multiple studies assessing the healthcare value formula have all come to similar conclusions: chiropractic care is highly cost-effective. (157, 158, 163, 164, 185-189)
Cost Comparison by Provider Type
Extensive systematic review in 2004 compared chiropractic care to standard medical care and physical therapy for treatment of musculoskeletal pain and highlighted a growing trend in the research:
Manual therapy techniques [including chiropractic manipulation] were more cost-effective than usual general practitioner care…for improving low back and shoulder pain/disability. (157)
Multiple other studies have come to similar conclusions:
A claims analysis of Blue Cross Blue Shield showed that when care for low back pain was initiated with a doctor of chiropractic (DC), overall healthcare costs for management of that case were reduced by nearly 40 percent when compared to care initiated with a medical doctor (MD). (163)

A similar cost analysis examining treatment of various spine, hip, and shoulder problems found costs to be significantly lower when management was initiated by a DC vs. MD. (164)

The British Medical Journal found an even more significant disparity:
The total costs of manual therapy were around one-third of the costs of physiotherapy and general practitioner care. (158) see below

Ancillary Costs – Healthcare Referrals
Generally speaking, health care costs rise as additional providers enter the clinical picture through referral. One of the biggest determinations in cost expectation and multiplication is the choice of provider at the start of the process. It also has a significant effect on likelihood of future referrals, tests, and procedures performed.
Several studies have shown that patients who initiate care with chiropractors end up seeing fewer total providers throughout the course of case management without an overall effect on clinical outcomes. (165-167) Data from Optum health showed that on average, patients who initiate care with a chiropractor see an average of 1.7 different providers by comparison to 3.2 different providers when initiating care from other specialties. (167)

Ancillary Costs – Surgery
By and large, most musculoskeletal problems achieve resolution without the need for surgical intervention. In addition, many issues once thought to be exclusively surgical are now being effectively managed conservatively. A study out of the Global Spine Journal in 2020 found that 97% of lumbar disc herniations are successfully managed without the need for surgical intervention. (168)
Another study out of Spine found that approximately 42.7% of injured workers who first saw a surgeon had surgery, in contrast to only 1.5% of those who sought care with a chiropractor. (166)

Ancillary Costs – Opioids & Other Drugs
While Covid has largely taken center stage the last 2 years as the pandemic, it should be noted that this country is still very much in the grips of an opioid pandemic. A cursory search of the CDC website shows that in last year alone deaths related to opioid use topped 75,000. This is further compounded by that fact that time and time again, research shows that these drugs, and others like them, are largely ineffective for managing mechanical musculoskeletal problems like back pain. (169-173)

Between 2000-2010, overdose death rates and substance use rates saw an increase of 3-4 fold – mirroring the overall increase in sales of these particular prescription pain relievers – with expectations that 2010-2020 will see show similar increases. (175)
Thankfully alternative treatments like chiropractic care may be able to play a larger role in mitigation of this unfortunate situation:
A 2019 Pain Medicine systematic review found that patients participating in chiropractic care were 64% less likely to receive an opioid prescription than nonusers. (176)

Another review from the same journal in the same year found that patients with back pain who engaged with chiropractic care exhibited “half the risk of filling an opioid prescription” over the following six years by comparison to those who did not. (177)

Ancillary Costs – Hospitalizations, Surgery & Medication
It is easy to assume that the addition of specialty to any care plan would automatically increase overall cost of care and reduce the Value equation discussed earlier in this blog. Fortunately, this is not always the case.
One 4-year study out of JMPT demonstrated that integration of chiropractic into the standard medical model of care can substantially decrease healthcare expenditures. (157)

Value to Healthcare Plans
An Optum Healthcare review concluded that healthcare plans which formally incorporate chiropractic care typically realize a 2:1 return for every dollar spent. (178)

Because of our ability to deliver high-value care with lower secondary costs, its easy to see how chiropractors become more appealing to patients seeking care for musculoskeletal pain and to the companies who insure them.
Conclusion
From the advantages in cost-effectiveness, value improvements when integrated in the medical model, lack of adverse reactions by comparison to drugs and savings for health insurance companies, its easy to see the value of seeking care with a doctor of chiropractic for musculoskeletal pain.
If you or anyone you know is in pain but is hesitant to seek care due to the perceived cost, I hope you would give this post your consideration. Thanks again for reading and look for the fourth and final part of this series Safety in the weeks to come.
References
- Bertelsman TJ, Steele BC, Gower JG. 2021 ChiroUp Network Dataset: Statistical Reporting of 631,970 Clinical Diagnoses Collected from 2212 Evidence-Based Chiropractic Providers Between July 2019- June 2021. Accessed on 07/30/2021 from Link
- Sawyer CE, Kassak K. Patient satisfaction with chiropractic care. Journal of Manipulative and Physiological Therapeutics. 1993 Jan 1;16(1):25-32. Link
- Gemmell HA, Hayes BM. Patient satisfaction with chiropractic physicians in an independent physicians’ association. Journal of manipulative and physiological therapeutics. 2001 Nov 1;24(9):556-9. Link
- Hertzman-Miller RP, Morgenstern H, Hurwitz EL, Yu F, Adams AH, Harber P, Kominski GF. Comparing the satisfaction of low back pain patients randomized to receive medical or chiropractic care: results from the UCLA low-back pain study. American Journal of Public Health. 2002 Oct;92(10):1628-33. Link
- Nyiendo J, Haas M, Goldberg B, Sexton G. Patient characteristics and physicians’ practice activities for patients with chronic low back pain: a practice-based study of primary care and chiropractic physicians. Journal of manipulative and physiological therapeutics. 2001 Feb 1;24(2):92-100. Link
- Nyiendo J, Haas M, Goodwin P. Patient characteristics, practice activities, and one-month outcomes for chronic, recurrent low-back pain treated by chiropractors and family medicine physicians: a practice-based feasibility study. Journal of Manipulative and physiological Therapeutics. 2000 May 1;23(4):239-45. Link
- Gaumer G. Factors associated with patient satisfaction with chiropractic care: survey and review of the literature. Journal of manipulative and physiological therapeutics. 2006 Jul 1;29(6):455-62. Link
- Nyiendo J, Haas M, Goodwin P. Patient characteristics, practice activities, and one-month outcomes for chronic, recurrent low-back pain treated by chiropractors and family medicine physicians: a practice-based feasibility study. Journal of Manipulative and physiological Therapeutics. 2000 May 1;23(4):239-45. Link
- Goertz CM, Long CR, Hondras MA, Petri R, Delgado R, Lawrence DJ, Owens EF, Meeker WC. Adding chiropractic manipulative therapy to standard medical care for patients with acute low back pain: results of a pragmatic randomized comparative effectiveness study. Spine. 2013 Apr 15;38(8):627-34. Link
- QualtricsXM. What is NPS? Your ultimate guide to Net Promoter Score. QualtricsXM. Link
- Reichheld FF. The one number you need to grow. Harvard business review. 2003 Dec 1;81(12):46-55.
- Liyakasa K. Customer Experience Is Critical in Net Promoter Benchmarks. CRM Magazine. 2012 Jun;16(6):16-. Link
- Stein N, Brooks K. A fully automated conversational artificial intelligence for weight loss: longitudinal observational study among overweight and obese adults. JMIR diabetes. 2017 Nov 1;2(2):e8590. Link
- Wilberforce M, Batten E, Challis D, Davies L, Kelly MP, Roberts C. The patient experience in community mental health services for older people: a concept mapping approach to support the development of a new quality measure. BMC health services research. 2018 Dec;18(1):1-1. Link
- Powell RE, Stone D, Hollander JE. Patient and health system experience with implementation of an enterprise-wide telehealth scheduled video visit program: mixed-methods study. JMIR medical informatics. 2018;6(1):e10. Link
- Busby M, Matthews R, Burke F, Mullins A, Shumacher K. Is any particular aspect of perceived quality associated with patients tending to promote a dental practice to their friends and colleagues? Br Dent J. 2015;218(6):E12. doi:10.1038/sj.bdj.2015.229
- Kinney WC. A simple and valuable approach for measuring customer satisfaction. Otolaryngology—Head and Neck Surgery. 2005 Aug;133(2):169-72. Link
- Koladycz R, Fernandez G, Gray K, Marriott H. The Net Promoter Score (NPS) for insight into client experiences in sexual and reproductive health clinics. Global Health: Science and Practice. 2018 Oct 3;6(3):413-24. Link
- NBCE. Practice Analysis of Chiropractic 2015. Chapter 1. National Board of Chiropractic Examiners. Link
- Stochkendahl MJ, Rezai M, Torres P, Sutton D, Tuchin P, Brown R, Côté P. The chiropractic workforce: a global review. Chiropractic & manual therapies. 2019 Dec;27(1):1-9. Link
- Grigore. What is a Good Net Promoter Score? (2021 NPS Benchmark). Retently. 2021 Apr. Link
- VisitPay. What’s Your Score? Why Net Promoter Score Matters in Healthcare [ebook]. VisitPay. 2021 Mar. Link
- WD Partners. Healthcare: Who Survives?. WD Partners Inc. 2019. Link
- Shalen P. Primary Care Providers. Spine-Health. 2000 Nov. Link
- Hedges L, Couey C. How Patients Use Online Reviews. Software Advice. 2020 Apr. Link
- Tashfeen Ekram T. Healthcare NPS is high: How to make even more out of PX. Beckers Hospital Review. 2017 Dec. Link
- Yelp dataset. Link
- Kadry B, Chu LF, Kadry B, Gammas D, Macario A. Analysis of 4999 online physician ratings indicates that most patients give physicians a favorable rating. Journal of medical Internet research. 2011;13(4):e95. Link
- Ornstein C. ProPublica. As reported in: Shots. Heath News from NPR. On Yelp, Doctors Get Reviewed Like Restaurants — And It Rankles. 08/06/2015. Accessed on 08/20/2021 at https://www.npr.org/sections/health-shots/2015/08/06/429624187/on-yelp-doctors-get-reviewed-like-restaurants-and-it-rankles
- Daskivich T, Luu M, Noah B, Fuller G, Anger J, Spiegel B. Differences in online consumer ratings of health care providers across medical, surgical, and allied health specialties: observational study of 212,933 providers. Journal of medical Internet research. 2018 May 9;20(5):e9160. Link
- Beliveau PJ, Wong JJ, Sutton DA, Simon NB, Bussières AE, Mior SA, French SD. The chiropractic profession: a scoping review of utilization rates, reasons for seeking care, patient profiles, and care provided. Chiropractic & manual therapies. 2017 Dec;25(1):1-7. Link
- Sinnott PL, Dally SK, Trafton J, Goulet JL, Wagner TH. Trends in diagnosis of painful neck and back conditions, 2002 to 2011. Medicine. 2017 May;96(20). Link
- Côté P, Cassidy JD, Carroll LJ, Kristman V. The annual incidence and course of neck pain in the general population: a population-based cohort study. Pain. 2004 Dec 1;112(3):267-73. Link
- Bronfort G, Haas M, Evans R, Leininger B, Triano J. Effectiveness of manual therapies: the UK evidence report. Chiropractic & osteopathy. 2010 Dec;18(1):1-33. Link
- Qaseem A, Wilt TJ, McLean RM, Forciea MA. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Annals of internal medicine. 2017 Apr 4;166(7):514-30. Link
- Stochkendahl MJ, Kjaer P, Hartvigsen J, Kongsted A, Aaboe J, Andersen M, Andersen MØ, Fournier G, Højgaard B, Jensen MB, Jensen LD. National Clinical Guidelines for non-surgical treatment of patients with recent onset low back pain or lumbar radiculopathy. European Spine Journal. 2018 Jan 1;27(1):60-75. Link
- Haldeman S, Dagenais S. What have we learned about the evidence-informed management of chronic low back pain?. The Spine Journal. 2008 Jan 1;8(1):266-77. Link
- Chou R, Qaseem A, Snow V, Casey D, Cross JT, Shekelle P, Owens DK. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Annals of internal medicine. 2007 Oct 2;147(7):478-91. Link
- von Heymann WJ, Schloemer P, Timm J, Muehlbauer B. Spinal high-velocity low amplitude manipulation in acute nonspecific low back pain: a double-blinded randomized controlled trial in comparison with diclofenac and placebo. Spine. 2013 Apr 1;38(7):540-8. Link
- Cecchi F, Molino-Lova R, Chiti M, Pasquini G, Paperini A, Conti AA, Macchi C. Spinal manipulation compared with back school and with individually delivered physiotherapy for the treatment of chronic low back pain: a randomized trial with one-year follow-up. Clinical rehabilitation. 2010 Jan;24(1):26-36. Link
- Bronfort G, Haas M, Evans RL, Bouter LM. Efficacy of spinal manipulation and mobilization for low back pain and neck pain: a systematic review and best evidence synthesis. The spine journal. 2004 May 1;4(3):335-56. Link
- Dagenais S, Gay RE, Tricco AC, Freeman MD, Mayer JM. NASS contemporary concepts in spine care: spinal manipulation therapy for acute low back pain. The Spine Journal. 2010 Oct 1;10(10):918-40. Link
- Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Kantner S, Ferguson AJ. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update. Link
- Giles LG, Muller R. Chronic spinal pain: a randomized clinical trial comparing medication, acupuncture, and spinal manipulation. Spine. 2003 Jul 15;28(14):1490-502. Link
- Von Heymann WJ, Schloemer P, Timm J, Muehlbauer B. Spinal HVLA-manipulation in acute nonspecific LBP: A double blinded randomized controlled trial in comparison with diclofenac and placebo. Spine. 2012.
- Bishop PB, Quon JA, Fisher CG, Dvorak MF. The Chiropractic Hospital-based Interventions Research Outcomes (CHIRO) study: a randomized controlled trial on the effectiveness of clinical practice guidelines in the medical and chiropractic management of patients with acute mechanical low back pain. The Spine Journal. 2010 Dec 1;10(12):1055-64. Link
- Wilkey A, Gregory M, Byfield D, McCarthy PW. A comparison between chiropractic management and pain clinic management for chronic low-back pain in a national health service outpatient clinic. The Journal of Alternative and Complementary Medicine. 2008 Jun 1;14(5):465-73. Link
- Parkin-Smith GF, Norman IJ, Briggs E, Angier E, Wood TG, Brantingham JW. A structured protocol of evidence-based conservative care compared with usual care for acute nonspecific low back pain: a randomized clinical trial. Archives of physical medicine and rehabilitation. 2012 Jan 1;93(1):11-20. Link
- Aure OF, Nilsen JH, Vasseljen O. Manual therapy and exercise therapy in patients with chronic low back pain: a randomized, controlled trial with 1-year follow-up. Spine. 2003 Mar 15;28(6):525-31. Link
- Paige NM, Miake-Lye IM, Booth MS, Beroes JM, Mardian AS, Dougherty P, Branson R, Tang B, Morton SC, Shekelle PG. Association of spinal manipulative therapy with clinical benefit and harm for acute low back pain: systematic review and meta-analysis. Jama. 2017 Apr 11;317(14):1451-60. Link
- Coulter ID, Crawford C, Hurwitz EL, Vernon H, Khorsan R, Booth MS, Herman PM. Manipulation and mobilization for treating chronic low back pain: a systematic review and meta-analysis. The Spine Journal. 2018 May 1;18(5):866-79. Link
- Goertz CM, Long CR, Vining RD, Pohlman KA, Walter J, Coulter I. Effect of usual medical care plus chiropractic care vs usual medical care alone on pain and disability among US service members with low back pain: A comparative effectiveness clinical trial. JAMA network open. 2018 May 18;1(1):e180105-. Link
- Astin JA, Ernst E. The effectiveness of spinal manipulation for the treatment of headache disorders: a systematic review of randomized clinical trials. Cephalalgia. 2002 Oct;22(8):617-23. Link
- Rist PM, Bernstein C, Kowalski M, Osypiuk K, Connor JP, Vining R, Long CR, Macklin EA, Wayne PM. Multimodal chiropractic care for migraine: A pilot randomized controlled trial. Cephalalgia. 2020 Oct 13:0333102420963844. Link
- Brønfort G, Nilsson N, Haas M, Evans RL, Goldsmith CH, Assendelft WJ, Bouter LM. Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database of Systematic Reviews. 2004(3). Link
- Rist PM, Hernandez A, Bernstein C, Kowalski M, Osypiuk K, Vining R, Long CR, Goertz C, Song R, Wayne PM. The Impact of Spinal Manipulation on Migraine Pain and Disability: A Systematic Review and Meta-Analysis. Headache: The Journal of Head and Face Pain. 2019 Apr;59(4):532-42. Link
- Tuchin PJ, Pollard H, Bonello R. A randomized controlled trial of chiropractic spinal manipulative therapy for migraine. Journal of manipulative and physiological therapeutics. 2000 Feb 1;23(2):91-5. Link
- Bryans R, Descarreaux M, Duranleau M, Marcoux H, Potter B, Ruegg R, Shaw L, Watkin R, White E. Evidence-based guidelines for the chiropractic treatment of adults with headache. Journal of manipulative and physiological therapeutics. 2011 Jun 1;34(5):274-89. Link
- Harris SP. Chiropractic management of a patient with migraine headache. Journal of chiropractic medicine. 2005;4(1):25. Link
- Biondi DM. Physical treatments for headache: a structured review. Headache: The Journal of Head and Face Pain. 2005 Jun;45(6):738-46. Link
- Bronfort G, Assendelft WJ, Evans R, Haas M, Bouter L. Efficacy of spinal manipulation for chronic headache: a systematic review. Journal of manipulative and physiological therapeutics. 2001 Sep 1;24(7):457-66. Link
- Noudeh YJ, Vatankhah N, Baradaran HR. Reduction of current migraine headache pain following neck massage and spinal manipulation. International journal of therapeutic massage & bodywork. 2012;5(1):5. Link
- 1 Jull G, Trott P, Potter H, Zito G, Niere K, Shirley D, Emberson J, Marschner I, Richardson C. A randomized controlled trial of exercise and manipulative therapy for cervicogenic headache. Spine. 2002 Sep 1;27(17):1835-43. Link
- McCrory, Penzlen, Hasselblad, Gray. Duke Evidence Report (2001).
- Antonia GC. Efficacy of manual and manipulative therapy in the perception of pain and cervical motion in patients with tension-type headache: a randomized, controlled clinical trial. Journal of chiropractic medicine. 2014 Mar 1;13(1):4-13. Link
- Dunning JR, Butts R, Mourad F, Young I, Fernandez-de-las Peñas C, Hagins M, Stanislawski T, Donley J, Buck D, Hooks TR, Cleland JA. Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache: a multi-center randomized clinical trial. BMC musculoskeletal disorders. 2016 Dec;17(1):64. Link
- Garcia JD, Arnold S, Tetley K, Voight K, Frank RA. Mobilization and manipulation of the cervical spine in patients with cervicogenic headache: any scientific evidence?. Frontiers in neurology. 2016 Mar 21;7:40. Link
- Varatharajan S, Ferguson B, Chrobak K, Shergill Y, Cote P, Wong JJ, Yu H, Shearer HM, Southerst D, Sutton D, Randhawa K. Are non-invasive interventions effective for the management of headaches associated with neck pain? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. European spine journal. 2016 Jul 1;25(7):1971-99. Link
- Malo-Urriés M, Tricás-Moreno JM, Estébanez-de-Miguel E, Hidalgo-García C, Carrasco-Uribarren A, Cabanillas-Barea S. Immediate Effects of Upper Cervical Translatoric Mobilization on Cervical Mobility and Pressure Pain Threshold in Patients With Cervicogenic Headache: A Randomized Controlled Trial. Journal of manipulative and physiological therapeutics. 2017 Nov 1;40(9):649-58. Link
- Haas M, Bronfort G, Evans R, Schulz C, Vavrek D, Takaki L, Hanson L, Leininger B, Neradilek MB. Dose-response and efficacy of spinal manipulation for care of cervicogenic headache: a dual-center randomized controlled trial. The Spine Journal. 2018 Oct 1;18(10):1741-54. Link
- Malo-Urriés M, Tricás-Moreno JM, Estébanez-de-Miguel E, Hidalgo-García C, Carrasco-Uribarren A, Cabanillas-Barea S. Immediate Effects of Upper Cervical Translatoric Mobilization on Cervical Mobility and Pressure Pain Threshold in Patients With Cervicogenic Headache: A Randomized Controlled Trial. Journal of manipulative and physiological therapeutics. 2017 Nov 1;40(9):649-58. Link
- Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, Fu R, Brodt ED, Wasson N, Kantner S, Ferguson AJ. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update. Link
- Fernandez M, Moore C, Tan J, Lian D, Nguyen J, Bacon A, Christie B, Shen I, Waldie T, Simonet D, Bussières A. Spinal manipulation for the management of cervicogenic headache: A systematic review and meta?analysis. European Journal of Pain. 2020 Jul 4. Link
- Dunning J, Butts R, Zacharko N, Fandry K, Young I, Wheeler K, Day J, Fernández-de-las-Peñas C. Spinal manipulation and perineural electrical dry needling in patients with cervicogenic headache: a multi-center randomized clinical trial. The Spine Journal. 2020 Oct 13. Link
- Abaspour O, Akbari M. Relationship between echogenicity of deep cervical muscles and pain laterality in subjects suffering from cervicogenic headache. CRANIO®. 2021 Jan 7:1-8. Link
- Govind J, Bogduk N. Sources of Cervicogenic Headache Among the Upper Cervical Synovial Joints. Pain Med. 2021 Jan 23:pnaa469. doi: 10.1093/pm/pnaa469. Epub ahead of print. PMID: 33484154. Link
- Reid SA, Rivett DA. Manual therapy treatment of cervicogenic dizziness: a systematic review. Manual therapy. 2005 Feb 1;10(1):4-13. Link
- Yaseen K, Hendrick P, Ismail A, Felemban M, Alshehri MA. The effectiveness of manual therapy in treating cervicogenic dizziness: a systematic review. Journal of physical therapy science. 2018;30(1):96-102. Link
- Jin X, Du HG, Qiao ZK, Huang Q, Chen WJ. The efficiency and safety of manual therapy for cervicogenic cephalic syndrome (CCS): A systematic review and meta-analysis. Medicine. 2021 Feb 26;100(8). Link
- Vernon H, Humphreys K, Hagino C. Chronic mechanical neck pain in adults treated by manual therapy: a systematic review of change scores in randomized clinical trials. Journal of Manipulative and Physiological Therapeutics. 2007 Mar 1;30(3):215-27. Link
- Korthals-de Bos IB, Müllner M, Hoving JL, van Tulder MW, Rutten-van Mölken MP, Adèr HJ, de Vet HC, Koes BW, Vondeling H, Bouter LM. Cost effectiveness of physiotherapy, manual therapy, and general practitioner care for neck pain: economic evaluation alongside a randomised controlled trialCommentary: Bootstrapping simplifies appreciation of statistical inferences. Bmj. 2003 Apr 26;326(7395):911-4. Link
- Hoving JL, Koes BW, de Vet HC, van der Windt DA, Assendelft WJ, van Mameren H, Devillé WL, Pool JJ, Scholten RJ, Bouter LM. Manual therapy, physical therapy, or continued care by a general practitioner for patients with neck pain: a randomized, controlled trial. Annals of internal medicine. 2002 May 21;136(10):713-22. Link
- Swenson RS. Therapeutic modalities in the management of nonspecific neck pain. Physical medicine and rehabilitation clinics of North America. 2003 Aug;14(3):605-27. Link
- Bronfort G, Evans R, Anderson AV, Svendsen KH, Bracha Y, Grimm RH. Spinal manipulation, medication, or home exercise with advice for actute and subacute neck pain: a randomized trial. Annals of Internal Medicine. 2012 Jan 3;156(1_Part_1):1-0. Link
- Leaver AM, Maher CG, Herbert RD, Latimer J, McAuley JH, Jull G, Refshauge KM. A randomized controlled trial comparing manipulation with mobilization for recent onset neck pain. Archives of physical medicine and rehabilitation. 2010 Sep 1;91(9):1313-8. Link
- Puentedura EJ, Landers MR, Cleland JA, Mintken P, Huijbregts P, Fernandez-De-Las-Peñas C. Thoracic spine thrust manipulation versus cervical spine thrust manipulation in patients with acute neck pain: a randomized clinical trial. journal of orthopaedic & sports physical therapy. 2011 Apr;41(4):208-20. Link
- Dunning JR, Cleland JA, Waldrop MA, Arnot C, Young I, Turner M, Sigurdsson G. Upper cervical and upper thoracic thrust manipulation versus nonthrust mobilization in patients with mechanical neck pain: a multicenter randomized clinical trial. journal of orthopaedic & sports physical therapy. 2012 Jan;42(1):5-18. Link
- Walker MJ, Boyles RE, Young BA, Strunce JB, Garber MB, Whitman JM, Deyle G, Wainner RS. The effectiveness of manual physical therapy and exercise for mechanical neck pain: a randomized clinical trial. Spine. 2008 Oct 15;33(22):2371-8. Link
- Boyles RE, Walker MJ, Young BA, Strunce JB, Wainner RS. The addition of cervical thrust manipulations to a manual physical therapy approach in patients treated for mechanical neck pain: a secondary analysis. journal of orthopaedic & sports physical therapy. 2010 Mar;40(3):133-40. Link
- Martínez-Segura R, Fernández-de-las-Peñas C, Ruiz-Sáez M, López-Jiménez C, Rodríguez-Blanco C. Immediate effects on neck pain and active range of motion after a single cervical high-velocity low-amplitude manipulation in subjects presenting with mechanical neck pain: a randomized controlled trial. Journal of manipulative and physiological therapeutics. 2006 Sep 1;29(7):511-7. Link
- Bernal-Utrera C, Gonzalez-Gerez JJ, Anarte-Lazo E, Rodriguez-Blanco C. Manual therapy versus therapeutic exercise in non-specific chronic neck pain: a randomized controlled trial. Trials. 2020 Dec;21(1):1-0. Link
- Saayman L, Hay C, Abrahamse H. Chiropractic manipulative therapy and low-level laser therapy in the management of cervical facet dysfunction: a randomized controlled study. Journal of manipulative and physiological therapeutics. 2011 Mar 1;34(3):153-63. Link
- Wong JJ, Shearer HM, Mior S, Jacobs C, Côté P, Randhawa K, Yu H, Southerst D, Varatharajan S, Sutton D, van der Velde G. Are manual therapies, passive physical modalities, or acupuncture effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the OPTIMa collaboration. The Spine Journal. 2016 Dec 1;16(12):1598-630. Link
- Gorrell LM, Beath K, Engel RM. Manual and instrument applied cervical manipulation for mechanical neck pain: a randomized controlled trial. Journal of manipulative and physiological therapeutics. 2016 Jun 1;39(5):319-29. Link
- Wong JJ, Shearer HM, Mior S, Jacobs C, Côté P, Randhawa K, Yu H, Southerst D, Varatharajan S, Sutton D, van der Velde G. Are manual therapies, passive physical modalities, or acupuncture effective for the management of patients with whiplash-associated disorders or neck pain and associated disorders? An update of the Bone and Joint Decade Task Force on Neck Pain and Its Associated Disorders by the OPTIMa collaboration. The Spine Journal. 2016 Dec 1;16(12):1598-630. Link
- Groeneweg R, van Assen L, Kropman H, Leopold H, Mulder J, Smits-Engelsman BC, Ostelo RW, Oostendorp RA, van Tulder MW. Manual therapy compared with physical therapy in patients with non-specific neck pain: a randomized controlled trial. Chiropractic & manual therapies. 2017 Dec;25(1):12. Link
- Whalen W, Farabaugh RJ, Hawk C, Minkalis AL, Lauretti W, Crivelli LS, Wyatt L, Sheppard M, Walters SA. Best-Practice Recommendations for Chiropractic Management of Patients With Neck Pain. Journal of Manipulative and Physiological Therapeutics. 2019 Dec 20. Link
- Bussieres AE, Stewart G, Al-Zoubi F, Decina P, Descarreaux M, Hayden J, Hendrickson B, Hincapie C, Page I, Passmore S, Srbely J. The treatment of neck pain–associated disorders and whiplash-associated disorders: a clinical practice guideline. Journal of manipulative and physiological therapeutics. 2016 Oct 1;39(8):523-64. Link
- Southerst D, Yu H, Randhawa K, Côté P, D’Angelo K, Shearer HM, Wong JJ, Sutton D, Varatharajan S, Goldgrub R, Dion S. The effectiveness of manual therapy for the management of musculoskeletal disorders of the upper and lower extremities: a systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Chiropractic & manual therapies. 2015 Dec;23(1):1-7. Link
- Crosbie J, Kilbreath SL, Hollmann L, York S. Scapulohumeral rhythm and associated spinal motion. Clinical biomechanics. 2008 Feb 1;23(2):184-92. Link
- Strunce JB, Walker MJ, Boyles RE, Young BA. The immediate effects of thoracic spine and rib manipulation on subjects with primary complaints of shoulder pain. Journal of Manual & Manipulative Therapy. 2009 Dec 1;17(4):230-6. Link
- Walser RF, Meserve BB, Boucher TR. The effectiveness of thoracic spine manipulation for the management of musculoskeletal conditions: a systematic review and meta-analysis of randomized clinical trials. Journal of Manual & Manipulative Therapy. 2009 Dec 1;17(4):237-46. Link
- Muth S, Barbe MF, Lauer R, McClure P. The effects of thoracic spine manipulation in subjects with signs of rotator cuff tendinopathy. Journal of orthopaedic & sports physical therapy. 2012 Dec;42(12):1005-16. Link
- Kardouni JR, Shaffer SW, Pidcoe PE, Finucane SD, Cheatham SA, Michener LA. Immediate changes in pressure pain sensitivity after thoracic spinal manipulative therapy in patients with subacromial impingement syndrome: a randomized controlled study. Manual therapy. 2015 Aug 1;20(4):540-6. Link
- Haik MN, Alburquerque-Sendín F, Silva CZ, Siqueira-Junior AL, Ribeiro IL, Camargo PR. Scapular kinematics pre–and post–thoracic thrust manipulation in individuals with and without shoulder impingement symptoms: a randomized controlled study. journal of orthopaedic & sports physical therapy. 2014 Jul;44(7):475-87. Link
- Boyles RE, Ritland BM, Miracle BM, Barclay DM, Faul MS, Moore JH, Koppenhaver SL, Wainner RS. The short-term effects of thoracic spine thrust manipulation on patients with shoulder impingement syndrome. Manual therapy. 2009 Aug 1;14(4):375-80. Link
- Vinuesa-Montoya S, Aguilar-Ferrándiz ME, Matarán-Peñarrocha GA, Fernández-Sánchez M, Fernández-Espinar EM, Castro-Sánchez AM. A preliminary randomized clinical trial on the effect of cervicothoracic manipulation plus supervised exercises vs a home exercise program for the treatment of shoulder impingement. Journal of chiropractic medicine. 2017 Jun 1;16(2):85-93. Link
- Belón-Perez P, Cuesta-Vargas AI. Immediate Effects of Thoracic Spine Manipulation Upon Shoulder Functionality in Patients With Sutured Rotator Cuff Repair: A Prospective Study. Journal of manipulative and physiological therapeutics. 2018 Sep 1;41(7):589-95. Link
- Dunning J, Butts R, Fernández-de-Las-Peñas C, Walsh S, Goult C, Gillett B, Arias-Buria JL, Garcia J, Young IA. Spinal Manipulation and Electrical Dry Needling in Patients With Subacromial Pain Syndrome: A Multicenter Randomized Clinical Trial. Journal of Orthopaedic & Sports Physical Therapy. 2020 Aug 28(0):1-46. Link
- Souza TA. Differential diagnosis and management for the chiropractor: protocols and algorithms. Jones & Bartlett Publishers; 2009 Oct 7.
- Bisset L, Paungmali A, Vicenzino B, Beller E. A systematic review and meta-analysis of clinical trials on physical interventions for lateral epicondylalgia. British journal of sports medicine. 2005 Jul 1;39(7):411-22. Link
- Vicenzino B, Paungmali A, Buratowski S, Wright A. Specific manipulative therapy treatment for chronic lateral epicondylalgia produces uniquely characteristic hypoalgesia. Manual therapy. 2001 Nov 1;6(4):205-12. Link
- Cleland JA, Flynn TW, Palmer JA. Incorporation of manual therapy directed at the cervicothoracic spine in patients with lateral epicondylalgia: a pilot clinical trial. Journal of manual & manipulative therapy. 2005 Jul 1;13(3):143-51. Link
- Cleland JA, Whitman JM, Fritz JM. Effectiveness of manual physical therapy to the cervical spine in the management of lateral epicondylalgia: a retrospective analysis. Journal of Orthopaedic & Sports Physical Therapy. 2004 Nov;34(11):713-24. Link
- Fernández-Carnero J, Fernández-de-las-Peñas C, Cleland JA. Immediate hypoalgesic and motor effects after a single cervical spine manipulation in subjects with lateral epicondylalgia. Journal of manipulative and physiological therapeutics. 2008 Nov 1;31(9):675-81. Link
- Javier González-Iglesias, Joshua A. Cleland, Maria del Rosario Gutierrez-Vega, and Cesar Fernández-de-las-Peñas, Multimodal Management Of Lateral Epicondylalgia In Rock Climbers :A prospective Case Series J Manipulative Physiol Ther 2011;34:635-642.
- Struijs PA, Damen PJ, Bakker EW, Blankevoort L, Assendelft WJ, van Dijk CN. Manipulation of the wrist for management of lateral epicondylitis: a randomized pilot study. Physical therapy. 2003 Jul 1;83(7):608-16. Link
- Lucado AM, Dale RB, Vincent J, Day JM. Do joint mobilizations assist in the recovery of lateral elbow tendinopathy? A systematic review and meta-analysis. Journal of Hand Therapy. 2018 Apr 26. Link
- Zunke P, Auffarth A, Hitzl W, Moursy M. The effect of manual therapy to the thoracic spine on pain-free grip and sympathetic activity in patients with lateral epicondylalgia humeri. A randomized, sample sized planned, placebo-controlled, patient-blinded monocentric trial. BMC Musculoskeletal Disorders. 2020 Dec;21(1):1-1. Link
- Reyhan AC, Sindel D, Dereli EE. The effects of Mulligan’s mobilization with movement technique in patients with lateral epicondylitis. Journal of Back and Musculoskeletal Rehabilitation. 2020 Jan 1(Preprint):1-9. Link
- Zunke P, Auffarth A, Hitzl W, Moursy M. The effect of manual therapy to the thoracic spine on pain-free grip and sympathetic activity in patients with lateral epicondylalgia humeri. A randomized, sample sized planned, placebo-controlled, patient-blinded monocentric trial. BMC Musculoskeletal Disorders. 2020 Dec;21(1):1-1. Link
- Ahmed A, Ibrar M, Arsh A, Wali S, Hayat S, Abass S. Comparing the effectiveness of Mulligan mobilization versus Cyriax approach in the management of patients with subacute lateral epicondylitis. Journal of the Pakistan Medical Association. 2020 Oct 15:1-1. Link
- Page MJ, O’Connor D, Pitt V, Massy, Westropp N. Exercise and mobilisation interventions for carpal tunnel syndrome. Cochrane Database of Systematic Reviews. 2012(6). Link
- Sault JD, Jayaseelan DJ, Mischke JJ, Post AA. The Utilization of Joint Mobilization As Part of a Comprehensive Program to Manage Carpal Tunnel Syndrome: A Systematic Review. Journal of Manipulative and Physiological Therapeutics. 2020 Aug 26. Link
- Brantingham JW, Williams AM, Parkin-Smith GF, Weston P, Wood T. A controlled, prospective pilot study of the possible effects of chiropractic manipulation in the treatment of osteo-arthritis of the hip. European Journal Of Chiropractic. 2003;51(3):149-66.
- Hoskins W, McHardy A, Pollard H, Windsham R, Onley R. Chiropractic treatment of lower extremity conditions: a literature review. Journal of manipulative and physiological therapeutics. 2006 Oct 1;29(8):658-71. Link
- Brantingham JW, Bonnefin D, Perle SM, Cassa TK, Globe G, Pribicevic M, Hicks M, Korporaal C. Manipulative therapy for lower extremity conditions: update of a literature review. Journal of manipulative and physiological therapeutics. 2012 Feb 1;35(2):127-66. Link
- MacDonald CW, Whitman JM, Cleland JA, Smith M, Hoeksma HL. Clinical outcomes following manual physical therapy and exercise for hip osteoarthritis: a case series. Journal of Orthopaedic & Sports Physical Therapy. 2006 Aug;36(8):588-99. Link
- Brantingham JW, Globe GA, Cassa TK, Globe D, Pollard H, Lee F, Bates C, Jensen M, Mayer S, Korporaal C, de Luca K. Research & Science. A Single-Group Pre-Test, Post-Test Design Using Full Kinetic Chain Manipulative Therapy with Rehabilitation in the Treatment of 27 Patients with Hip Osteoarthritis. Journal of the American Chiropractic Association. 2010 Aug 1;47(6). Link
- Brantingham JW, Globe GA, Cassa TK, Globe D, Pollard H, Lee F, Bates C, Jensen M, Mayer S, Korporaal C, de Luca K. Research & Science. A Single-Group Pre-Test, Post-Test Design Using Full Kinetic Chain Manipulative Therapy with Rehabilitation in the Treatment of 27 Patients with Hip Osteoarthritis. Journal of the American Chiropractic Association. 2010 Aug 1;47(6). Link
- De Luca K, Pollard H, Brantingham J, Globe G, Cassa T. Chiropractic management of the kinetic chain for the treatment of hip osteoarthritis: an Australian case series. Journal of manipulative and physiological therapeutics. 2010 Jul 1;33(6):474-9. Link
- Brantingham JW, Parkin-Smith G, Cassa TK, Globe GA, Globe D, Pollard H, deLuca K, Jensen M, Mayer S, Korporaal C. Full kinetic chain manual and manipulative therapy plus exercise compared with targeted manual and manipulative therapy plus exercise for symptomatic osteoarthritis of the hip: a randomized controlled trial. Archives of physical medicine and rehabilitation. 2012 Feb 1;93(2):259-67. Link
- Abbott JH, Robertson MC, Chapple C, Pinto D, Wright AA, de la Barra SL, Baxter GD, Theis JC, Campbell AJ, MOA Trial Team. Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: a randomized controlled trial. 1: clinical effectiveness. Osteoarthritis and Cartilage. 2013 Apr 1;21(4):525-34. Link
- Zhang W, Moskowitz R, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis and Cartilage. 2008;16:137-162.
- Poulsen E, Hartvigsen J, Christensen HW, Roos EM, Vach W, Overgaard S. Patient education with or without manual therapy compared to a control group in patients with osteoarthritis of the hip. A proof-of-principle three-arm parallel group randomized clinical trial. Osteoarthritis and Cartilage. 2013 Oct 1;21(10):1494-503. Link
- French HP, Cusack T, Brennan A, Caffrey A, Conroy R, Cuddy V, FitzGerald OM, Gilsenan C, Kane D, O’Connell PG, White B. Exercise and manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the hip: a multicenter randomized controlled trial. Archives of physical medicine and rehabilitation. 2013 Feb 1;94(2):302-14. Link
- Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis care & research. 2012 Apr;64(4):465-74. Link
- De Luca K, Pollard H, Brantingham J, Globe G, Cassa T. A randomized controlled trial of chiropractic management of the lower limb kinetic chain for the treatment of hip osteoarthritis: a study protocol. Journal of chiropractic medicine. 2011 Jun 1;10(2):86-92. Link
- Zhang W, Nuki G, Moskowitz RW, Abramson S, Altman RD, Arden NK, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M, Dougados M. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis and cartilage. 2010 Apr 1;18(4):476-99. Link
- Vaarbakken K, Elisabeth Ljunggren A. Superior effect of forceful compared with standard traction mobilizations in hip disability?. Advances in physiotherapy. 2007 Jan 1;9(3):117-28. Link
- Dwyer L, Parkin-Smith GF, Brantingham JW, Korporaal C, Cassa TK, Globe G, Bonnefin D, Tong V. Manual and manipulative therapy in addition to rehabilitation for osteoarthritis of the knee: assessor-blind randomized pilot trial. Journal of manipulative and physiological therapeutics. 2015 Jan 1;38(1):1-21. Link
- Dimou ES, Brantingham JW, Wood T. A randomized, controlled trial (with blinded observer) of chiropractic manipulation and Achilles stretching vs. orthotics for the treatment of plantar fasciitis. Journal of the American Chiropractic Association. 2004 Sep 1;41(9). Link
- Bleakley CM, McDonough SM, MacAuley DC. Some conservative strategies are effective when added to controlled mobilisation with external support after acute ankle sprain: a systematic review. Australian Journal of Physiotherapy. 2008 Jan 1;54(1):7-20. Link
- Green T, Refshauge K, Crosbie J, Adams R. A randomized controlled trial of a passive accessory joint mobilization on acute ankle inversion sprains. Physical therapy. 2001 Apr 1;81(4):984-94. Link
- Denegar CR, Hertel J, Fonseca J. The effect of lateral ankle sprain on dorsiflexion range of motion, posterior talar glide, and joint laxity. Journal of Orthopaedic & Sports Physical Therapy. 2002 Apr;32(4):166-73. Link
- van der Wees PJ, Lenssen AF, Hendriks EJ, Stomp DJ, Dekker J, de Bie RA. Effectiveness of exercise therapy and manual mobilisation in acute ankle sprain and functional instability: a systematic review. Australian Journal of Physiotherapy. 2006 Jan 1;52(1):27-37. Link
- Eisenhart AW, Gaeta TJ, Yens DP. Osteopathic manipulative treatment in the emergency department for patients with acute ankle injuries. The Journal of the American Osteopathic Association. 2003 Sep 1;103(9):417-21.
- Loudon JK, Reiman MP, Sylvain J. The efficacy of manual joint mobilisation/manipulation in treatment of lateral ankle sprains: a systematic review. Br J Sports Med. 2014 Mar 1;48(5):365-70. Link
- Fraser JJ, Saliba SA, Hart JM, Park JS, Hertel J. Effects of midfoot joint mobilization on ankle-foot morphology and function following acute ankle sprain. A crossover clinical trial. Musculoskeletal Science and Practice. 2020 Apr 1;46:102130. Link
- Weerasekara I, Osmotherly P, Snodgrass S, Marquez J, de Zoete R, Rivett DA. Clinical benefits of joint mobilization on ankle sprains: a systematic review and meta-analysis. Archives of physical medicine and rehabilitation. 2018 Jul 1;99(7):1395-412. Link
- Gogate N, Satpute K, Hall T. The effectiveness of mobilization with movement on pain, balance and function following acute and sub acute inversion ankle sprain–A randomized, placebo controlled trial. Physical Therapy in Sport. 2020 Dec 23. Link
- Nguyen AP, Pitance L, Mahaudens P, Detrembleur C, David Y, Hall T, Hidalgo B. Effects of Mulligan Mobilization with Movement in Subacute Lateral Ankle Sprains: A Pragmatic Randomized Trial. Journal of Manual & Manipulative Therapy. 2021 Feb 28:1-2. Link
- Brantingham JW, Cassa TK, Bonnefin D, Pribicevic M, Robb A, Pollard H, Tong V, Korporaal C. Manipulative and multimodal therapy for upper extremity and temporomandibular disorders: a systematic review. Journal of manipulative and physiological therapeutics. 2013 Mar 1;36(3):143-201. Link
- Pilar Mansilla-Ferragut, DO, César Fernández-de-las Peñas, DO, PhD, Francisco Alburquerque-Sendi`n, DO, PhD, Joshua A. Cleland, PhD, and Juan José Boscá-Gandi. DO J Manipulative Physiol Ther 2009;32:101-106
- Reynolds B, Puentedura EJ, Kolber MJ, Cleland JA. Effectiveness of cervical spine high velocity low amplitude thrust added to behavioral education, soft tissue mobilization, and exercise in individuals with temporomandibular disorder (TMD) with myalgia: A randomized clinical trial. Journal of Orthopaedic & Sports Physical Therapy. 2020 Jan 6(0):1-40. Link
- Schneider M, Haas M, Glick R, Stevans J, Landsittel D. A comparison of spinal manipulation methods and usual medical care for acute and Sub-acute low back pain: a randomized clinical trial. Spine. 2015 Feb 15;40(4):209. Link
- Sarnat RL, Winterstein J. Clinical and cost outcomes of an integrative medicine IPA. Journal of Manipulative and Physiological Therapeutics. 2004 Jun 1;27(5):336-47. Link
- Korthals-de Bos IB, Müllner M, Hoving JL, van Tulder MW, Rutten-van Mölken MP, Adèr HJ, de Vet HC, Koes BW, Vondeling H, Bouter LM. Cost effectiveness of physiotherapy, manual therapy, and general practitioner care for neck pain: economic evaluation alongside a randomised controlled trialCommentary: Bootstrapping simplifies appreciation of statistical inferences. Bmj. 2003 Apr 26;326(7395):911-4. Link
- Qaseem A, Wilt TJ, McLean RM, Forciea MA. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Annals of internal medicine. 2017 Apr 4;166(7):514-30. Link
- FDA. FDA Education Blueprint for Health Care Providers Involved in the Management or Support of Patients with Pain. U.S. Food and Drug Administration. Link
- Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. Jama. 2016 Apr 19;315(15):1624-45. Link
- United States Bone and Joint Initiative: The Burden of Musculoskeletal Diseases in the United States (BMUS), Third Edition, 2014. Rosemont, IL. Link
- Liliedahl RL, Finch MD, Axene DV, Goertz CM. Cost of care for common back pain conditions initiated with chiropractic doctor vs medical doctor/doctor of osteopathy as first physician: experience of one Tennessee-based general health insurer. Journal of manipulative and physiological therapeutics. 2010 Nov 1;33(9):640-3. Link
- Houweling TA, Braga AV, Hausheer T, Vogelsang M, Peterson C, Humphreys BK. First-contact care with a medical vs chiropractic provider after consultation with a Swiss telemedicine provider: comparison of outcomes, patient satisfaction, and health care costs in spinal, hip, and shoulder pain patients. Journal of manipulative and physiological therapeutics. 2015 Sep 1;38(7):477-83. Link
- Hinkeldey N, Okamoto C, Khan J. Spinal Manipulation and Select Manual Therapies: Current Perspectives. Physical Medicine and Rehabilitation Clinics. 2020 Nov 1;31(4):593-608. Link
- Keeney BJ, Fulton-Kehoe D, Turner JA, Wickizer TM, Chan KC, Franklin GM. Early predictors of lumbar spine surgery after occupational back injury: results from a prospective study of workers in Washington State. Spine. 2013 May 15;38(11):953. Link
- Elton D. The distribution and analysis of annualized claims data for more than 3.7 million commercial health plan members. Data retrieved from the UnitedHealthcare national commercial claims database, July 1, 2013–June 30, 2014. 2014 Nov.
- Lilly DT, Davison MA, Eldridge CM, Singh R, Montgomery EY, Bagley C, Adogwa O. An Assessment of Nonoperative Management Strategies in a Herniated Lumbar Disc Population: Successes Versus Failures. Global Spine Journal. 2020 Jul 7:2192568220936217. Link
- Schreijenberg M, Lin CW, Mclachlan AJ, Williams CM, Kamper SJ, Koes BW, Maher CG, Billot L. Paracetamol is ineffective for acute low back pain even for patients who comply with treatment: complier average causal effect analysis of a randomized controlled trial. Pain. 2019 Dec 1;160(12):2848-54. Link
- 52. van der Gaag WH, Roelofs PD, Enthoven WT, van Tulder MW, Koes BW. Non‐steroidal anti‐inflammatory drugs for acute low back pain. Cochrane Database of Systematic Reviews. 2020(4). Link
- Abdel Shaheed C, Maher CG, Williams KA, McLachlan AJ. Efficacy and tolerability of muscle relaxants for low back pain: systematic review and meta‐analysis. European Journal of Pain. 2017 Feb;21(2):228-37. Link
- Ebell MH. Gabapentin and Pregabalin Not Effective for Low Back Pain with or Without Radiculopathy. American family physician. 2019 Mar 15;99(6). Link
- Ashworth J, Green DJ, Dunn KM, Jordan KP. Opioid use among low back pain patients in primary care: Is opioid prescription associated with disability at 6-month follow-up?. PAIN®. 2013 Jul 1;154(7):1038-44. Link
- NSC. Addressing the Opioid Crisis. National Safety Council. Accessed on 08/20/2021 from https://www.nsc.org/home-safety/safety-topics/opioids
- Paulozzi MD, Jones PharmD, et al. Vital Signs: Overdoses of Prescription Opioid Pain Relievers – United State, 1999-2008. Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Center for Disease Control and Prevention. 2011:60:5.
- Corcoran KL, Bastian LA, Gunderson CG, Steffens C, Brackett A, Lisi AJ. Association between chiropractic use and opioid receipt among patients with spinal pain: a systematic review and meta-analysis. Pain Medicine. 2020 Feb 1;21(2):e139-45. Link
- Whedon JM, Toler AW, Kazal LA, Bezdjian S, Goehl JM, Greenstein J. Impact of chiropractic care on use of prescription opioids in patients with spinal pain. Pain Medicine. 2020 Dec 25;21(12):3567-73. Link
- Feldman V, Return on investment analysis of Optum offerings — assumes Network/UM/Claims services; Optum Book of Business Analytics 2013.